Theory question paper: April 2016

Dr Amit Ghawade
Read the questions carefully and answer to the point neatly and legibly.
Do not leave any blank pages between two answers
Indicate the question number correctly for the answer in the margin space.
Answer the parts of a Single question together.
Start the answer to a question on a fresh page or leave adequate space  between two answers.
Draw table/diagrams/flowcharts wherever appropriate.
                        Paper – I

Write short notes on:
1.
a) Adrenal steroid hormone synthesis                              5+(2+3)
b) Outline the biochemical consequences of defects in the classical 21-hydroxylase deficiency and its management.

2.
a) Structure of glomerulus with diagrammatic representation. (6+4)
b) What are the glomerular changes in rapidly progressive glomerulonephritis.

3. Enumerate the five high impact activities under RMNCH+A programme. 2+2+2+2+2

4. How is plasma osmolality calculated? Discuss its determinants. What are the diagnostic criteria of SIADH (Syndrome of inappropriate ADH secretion) (3+4)+3


5.
a) Steps to curb female infanticide.  (5+5)
b) Role of micronutrients in pediatric health and disease.

6.
a) Virology and epidemiology of Swine-flu. (1+2)+3+(2+2)
b) How is the disease categorized according to Govt. of India guidelines.
c) Mention which children need to be immunized and who need to be given medication for the disease.

7.
a) EVidence based medlcine. (6+4)
b) Forest plot in meta-analysis.

8.
a) Clinical trials - Phase I, Phase II, Phase III & Phase IV. (5+5)
b) Ethics in biomedical research.

9.
a) Laws of adoption in India Define translocation. Write the Inheritance pattern for translocations. Describe clinical features of anyone translocation disorder. (4+6)
b) Enumerate 4 common neuronal migration disorders and their clinical features in brief.

10. Millennium Development Goals (MDG). (6+4)


                                Paper – II


1.
(a) Causes of neonatal anaemia.  5+5
(b) Cyanosis in newborn.

2. Aetiology, pathogenesis, linical features and management  of hypophosphataemia. 2+3+2+3

3. 
(a) What is Severe Acute Malnutrition (SAM)?  2+2+6
(b) What are the clinical signs of SAM?
(c) Management  of SAM in an one year old child weighing  5 kg.

4. An 8 year old child is brought with history of convulsions  and altered sensorium, his BP is 180/110 mmHg . Discuss the differential diagnosis, laboratory  investigations  and management  of this patient. 3+3+4

5.
(a) Apnoea of prematurity 5+5
(b) Retinopathy of prematurity.


6. Management  of steroid resistant and steroid dependent nephritic syndrome. 5+5


7. Management  of   5+5
 (a )Acute myeloid  leukaemia
 (b) Aplastic  anaemia .

8. 
(a) Diagnosis and management  of pertussis 5+5
(b) VAPP  (Vaccine Associated  Paralytic  PoliomyelitiS).

9.
(a) Fluoride  and disease  2+4+4
(b) Hypervitaminosis   A
(c) Hypervitaminosis   D

10.
(a) CSF formation and CSF circulation. 4+(3+3)
(b) Enumarate the causes  and management  of
        1. Communicating   hydrocephalus   
        2. Non-communicating hydrocephalus  

                         Paper – III

1. Pathcphysioloqy   and management  of   5+5

(a) Organophosphorus   poisoning.
(b) Scorpion  bite.

2. What  are the biochemical  criteria  for the diagnosis  of Diabetic Ketacidosis (DKA)?  What  are  the goals  of therapy?  How will you manage  a 7 year child with DKA?  3+3+4

3. Etiology,   pathogenesis,   clinical  features  and  management   of cardigenic  shock? 2+3+2+3

4. Describe  the  symbols  used  in pedigree  chart.  Draw  pedigree charts  over four generation  depicting. 4+(3+3)
(a) X-linked  dominant  disease 
(b) X linked recessive disease.

5. Define  severe  dengue   Describe  the WHO  guidelines  for  Its management. Enumerate  the complications  of severe dengue. 2+4+4


6. 
(a) Bioterrorism        3+3+4
(b) Radiation  sickness
(c) Congenital  cataract

7.

(a) Modified  Glasgow  Coma Scale for children and Infants.  5+2+3
(b) Its advantages  and disadvantages.

(c) What  is AVPU  Pediatric Response Scale?

8. Define fulminant Hepatic   failure.   Write   stages Hepatic Encephalopathy. Outline steps of Its management.  2+3+5


9.

(a) Autistic  spectrum  disorders 3+3+4
(b) Wiskott-Aldrich   syndrome .
(c) Graft versus host disease

10.
(a) Hypernatrerma. 3+3+4
(b) Hyperkalemia.
(c) Non-pharmacoglogic strategies  for pain management.


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